De Novo Approach for Finding Post Translational Modifications.
نویسندگان
چکیده
منابع مشابه
Post-translational modifications of tubulin
Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism ...
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Peptide identification by tandemmass spectrometry (MS/MS) and database searching is becoming the standard high-throughput technology in many areas of the life sciences. The analysis of post-translational modifications (PTMs) is a major source of complications in this area, which calls for efficient computational approaches. In this paper we describe PTMSearch, a novel algorithm in which the PTM...
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Fe-type nitrile hydratase (NHase) from Rhodococcus sp. N771 has a novel non-heme iron active center with two post-translationally modified cysteine residues, cysteine-sulfenic and -sulfinic acids. The modified residues are involved in the sequence motif, Cys-Xxx-Leu-Cys-Ser-Cys (Xxx = Ser(Fetype)/Thr(Co-type)), which is conserved among all known NHases as well as in the homologous enzyme, thioc...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.lb67-d